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Protamine Other Mechanisms

It has been appropriate that the majority of anaphylactic/anaphylactoid reactions are associated with accompaniment activation and the absolution of anaphylatoxins C3a and C5a. These actuate the cyclo-oxygenase alleyway of the arachidonic acerbic metabolism in yet anonymous cells, apparently aural the lung. As a result, thromboxane and prostaglandins are released. Thromboxane is the cardinal advocate amenable for the pulmonary vasoconstriction and, presumably, aswell for the bronchospasm during Protamine reactions.

 
The accident of adverse reactions to Protamine sulfate ambit from 0.06% to 27% and alter from balmy urticaria to anaphylactic shock and death.
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